Which skin cream is best for YOU? Ask your genes.
AQP3 gene along with CLDN1 are known to regulate skin hydration, skin barrier recovery and wound healing.
Order your DNA-based Skin Care reports to see which genetic variations contribute to your skin condition
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See which genetic variations contribute to your skin conditions
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About Silverberry Genomix
Silverberry Genomix is a personalized DNA-based wellness service which utilizes the latest advances in genomics science and machine learning methods (AI) to analyze more than 140 genetic predispositions.
Reports are generated in five packages: Nutrition, Fitness, Skin Care, Allergy Management and Personality Development.
Silverberry Reports use 23andMe, Ancestry.com or FTDNA Data to generate your wellness reports.
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Sample Report: Skin Dryness
Balanced level of hydration is absolutely fundamental for healthy facial and body skin. Aquaporin channels, a family of integral cell membrane proteins, play central role in keeping our skin hydrated by allowing the movement of water and glycerol across the cell membrane.
The expression of aquaporin channels in human skin is strongly affected by aging, chronic sun exposure, and inflammation.
The most abundant (and best studied) aquaporin in the skin is the AQP3 gene. It transports water, glycerol and small solutes (urea) across the plasma membrane, regulates skin hydration, skin barrier recovery and wound healing. Another group of genes expressed in skin are called claudins. They are tight junction membrane proteins that form paracellular barriers and pores that determine tight junction permeability.
Genetic variations in the AQP3 and CLDN1 genes result in their lower expression and reduced activity in epidermis leading to impairments in skin intrinsic hydration capacity, and skin dryness.