Which skin cream is best for YOU? Ask your genes.
The AQP3 and CLDN1 genes are known to regulate skin hydration, skin barrier recovery, and wound healing.
Order your DNA-based Skin Care reports to see which genetic variations contribute to your skin features.
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Discover the genetic variations that contribute to your skin features.
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About Silverberry Genomix
Silverberry Genomix is a personalized DNA-based wellness service which utilizes the latest advances in genomics science and machine learning methods (AI) to analyze more than 140 genetic predispositions.
Reports are generated in five packages: Nutrition, Fitness, Skin Care, Allergy Management and Personality Development.
Silverberry Reports use 23andMe, Ancestry.com or FTDNA Data to generate your wellness reports.
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Sample Report: Skin Dryness
Proper hydration is absolutely fundamental for healthy skin. Aquaporin channels, a family of integral cell membrane proteins, play a central role in keeping skin hydrated by allowing the movement of water and glycerol across the cell membrane.
The expression of aquaporin channels in human skin is strongly affected by aging, chronic sun exposure, and inflammation.
The most abundant (and best studied) aquaporin in the skin is the AQP3 gene. It transports water, glycerol, and small solutes (urea) across the plasma membrane. It regulates skin hydration, skin barrier recovery, and wound healing. Another group of genes expressed in skin cells are called claudins. They are tight junction membrane proteins, meaning they form connections between neighboring cells. These cell-to-cell connections (tight junctions) are used for communication and the transfer of resources. The claudins are among the most important components used to build these connection channels — they secure the perimeter (officially called the "paracellular barrier") and determine what gets in or out (with pores that determine tight junction permeability).
Genetic variations in the AQP3 and CLDN1 genes result in lower expression and reduced activity in epidermal cells. The reduced transfer of resources between cells can lead to impairments in the skin's intrinsic hydration capacity and produce skin dryness.