Caffeine: The Genetics Behind Your Love/Hate Relationship — Part 2

Caffeine: The Genetics Behind Your Love/Hate Relationship

This four-part series takes a deep-dive into the genetics behind caffeine consumption, taste, metabolism, and side effects.

 

Part 2: Caffeine’s Tasty Side

Some like it black, while others need a little cream and sugar. These coffee preferences may be the result of genetics. In fact, numerous genetic variants have been linked to taste perception. In some individuals, the taste receptors for bitter-tasting compounds, like caffeine, are less sensitive than the general population.

Bitter Taste Perception

As a survival mechanism, humans developed an adaptation to taste toxic compounds as bitter. Plants produce many toxic bitter-tasting compounds, developed as pesticides, to disincentivize consumption. In response, herbivores developed more potent liver enzymes to neutralize these toxins, while omnivores (like humans) developed enhanced detection and screening mechanisms. It is estimated that 75% of humans have a relatively robust detection system, but some individuals have a diminished ability to sense bitter compounds. These individuals are less sensitive to the bitter taste of caffeine.

The type 2 taste receptors, or TAS2Rs, are responsible for tasting bitter compounds and one member in particular is responsible for tasting caffeine — Taste 2 Receptor Member 46 (TAS2R46). Genetic variants of this gene have been linked to reduced taste sensitivity. Since taste is one of the key drivers of food preferences and dietary habits, genetic variants that make individuals less sensitive to caffeine could drive dietary behavior. Individuals who are less sensitive to the bitter taste of caffeine may need less cream and sugar to mask the bitterness in their morning cup of joe. However, they may also be more likely to consume greater quantities — putting them at greater risk of sleep disturbances or anxiety if this trait is paired with other genetic variants.

Caffeine Sources

Caffeine comes in two varieties — natural and synthetic.

The primary sources of natural caffeine are coffee, tea, and dark chocolate. These are derived from coffee beans, tea leaves, and cocoa beans.

The synthetic version of caffeine is produced in the lab with petroleum-based chemicals. It is often referred to as "anhydrous caffeine" on food labels and it is the version most often found in soft drinks and energy drinks.

Frequent consumers of natural caffeine sources, like coffee and tea, are noted to have better health than regular consumers of synthetic caffeine sources, like sodas (diet or regular) and energy drinks. It is unclear if this is a response to the type of caffeine or if it is a result of the phytonutrients (healthy plant compounds) that accompany natural sources of caffeine, but this distinction is important to note. Therefore, it is advisable to choose natural sources of caffeine. Caffeine content can vary dramatically by coffee bean or tea leaf variety, as well as by preparation method, so it is wise to check the caffeine content of a beverage before you drink it.

Daily Recommended Intake

According to the USDA's Dietary Guidelines, moderate coffee consumption can be part of a healthy diet. Moderate coffee consumption means 3-5 cups per day, providing approximately 200-400 mg of caffeine. For reference, one cup (8 oz) of brewed coffee contains 95 mg on average. A Starbucks Grande [16 oz] is a two-cup serving that provides 310 mg of caffeine. An identical serving of black tea will provide about 35 mg of caffeine, while green tea will give you 25 mg.

 

Check back soon for the next article in the series!

 

Caffeine: The Genetics Behind Your Love/Hate Relationship — Part 1

Caffeine: The Genetics Behind Your Love/Hate Relationship

This four-part series takes a deep-dive into the genetics behind caffeine consumption, taste, metabolism, and side effects.

 

Part 1: Caffeine’s Unpleasant Side

Caffeine is prized the world over for its ability to increase alertness and reduce fatigue. On the other hand, it has also been known to produce side effects of increased heart rate, jitters, anxiety, and insomnia. The major method by which caffeine produces its effects is by influencing the adenosine signaling pathway. Understanding this pathway is essential for understanding the side effects that can result from excessive caffeine consumption and the role genes play in side effects such as insomnia and anxiety.

Adenosine: Your Battery Meter

Adenosine is used as an indicator of current energy stores, and when energy stores are depleted it signals to slow everything down so that energy stores can be replenished. Adenosine is made when you burn ATP, the body's main energy currency. High levels of adenosine indicate that ATP is being burned faster than it is being made, sending a signal that an ongoing activity must be slowed. Adenosine acts as a sort of battery manager, as your cell phone's battery is depleted, background apps are shut off in order to conserve battery power for only essential operations. High levels of adenosine are why you feel fatigue after an intense workout and they are also why you feel tired or sleepy as your bedtime nears.

While very high levels of adenosine produce potent feelings of fatigue, a baseline or basal level of adenosine in your cells allows for wakefulness. When adenosine levels drop below this baseline, you experience feelings of alertness. Just as high levels of adenosine signal a lack of fuel, low levels of adenosine signal an abundance of fuel. Fuel demanding to be used! This is how caffeine works its magic.

Caffeine Hacks Your Battery Meter

Caffeine, and the byproducts of its metabolism, bind to adenosine receptors, block adenosine from binding, and in so doing, trick the cell into thinking that adenosine levels are low. This is the signal that there is fuel to burn, so energy and activity are increased. There are several different adenosine receptors, but caffeine and its metabolites target two in particular — the A1 and A2A receptors. These receptors are just the first step in a long signaling chain, so their triggering produces a series of effects.

Caffeine-Induced Insomnia

Genetic variants in the adenosine A1 and A2A receptors have also been associated with poor sleep in response to caffeine. Poor sleep can mean either a reduction in sleep quality, lots of tossing and turning, or reduction in sleep duration due to trouble staying asleep. The disruption of sleep produced by caffeine is not related to a person's ability to metabolize caffeine; instead, it is a function of the brain's initiation and control of sleep. In studies of individuals with nearly identical caffeine metabolism, and identical amounts of caffeine in their blood, people with caffeine-sensitive adenosine receptors suffered from worse sleep.

Caffeine-Induced Anxiety

One of the downstream effects of caffeine binding involves the neurotransmitter dopamine and may play a role in producing feelings of anxiety. While dopamine has often been described as "the pleasure chemical,” the neurotransmitter is involved in both reward-seeking behaviors and pain-avoidance behaviors. Reward-seeking behaviors are encouraged by triggering feelings of pleasure when a task is accomplished or an item is obtained. On the other hand, pain-avoidance behavior can be promoted by triggering feelings of fear and anxiety.

For example, when a child commits to a lengthy search for the cookie jar and they find it, they enjoy pleasure sensations along with their cookie. Tenacity and commitment are encouraged. On the other hand, if a child were to accidentally come into contact with a hot stove during their cookie search, feelings of pain and fear would wash over them. By promoting anxiety when near the stove, the child would be protected from further injury.

Genetic variants in both the adenosine A2A receptor [ADORA2A] and the dopamine D2 receptor [DRD2] have been associated with feelings of anxiety and stress in response to caffeine.

 

Check back soon for the next article in the series!

 

Silverberry Announces Wellness Ambassador Program

Silverberry Genomix designed the Wellness Ambassador Program to offer an opportunity for proactive wellness enthusiasts and friends to participate in the growing genomics market, and receive compensation for introducing DNA assessments to anyone with wellness goals.

San Francisco, August 24, 2018 - Silverberry Genomix, a pioneer in the use of DNA assessment for health and wellness, announces its new program, Wellness Ambassador. The Wellness Ambassador program enables individuals interested in health and wellness to play an active role in the genomics industry and earn revenue advocating health.

“As we witness a rapid growth in the use of genetic assessment for wellness, the need for educating consumers, fitness professionals, industry managers, and healthcare providers is imminent,” said Shayan Mashatian, CEO of Silverberry Genomix. “Many of us wellness and health enthusiasts always share useful tips and resources with each other. This program enables everyone with a proactive wellbeing mindset to inform the population about DNA services and monetize on their efforts”, he continued.

Those with existing relationships can benefit quickly, like personal trainers, registered dietitians, physicians, nutritionists, insurance brokers for health plans, wellness coaches, HR and employee benefit managers, and social influencers can leverage their existing platforms to become a Silverberry Wellness Ambassador.

The Structure of the Wellness ambassador Program is simple: Anyone can register, then introduce DNA assessments for health and wellness to individuals and entities. Once a provider or partner join and start using the services, the ambassador receives a percentage of the entire account, while managing it. Depending on account size or total revenue, program has made it possible for the residual income to exceed that of a full time job.

All active members of communities, wellness forums, websites, gyms, fitness centers, spas, and rehabilitation centers are well positioned to lead their networks forward in the genomics innovation. Especially those with existing relationships can benefit quickly, like personal trainers, registered dietitians, physicians, nutritionists, insurance brokers for health plans, wellness coaches, HR and employee benefit managers, and social influencers can leverage their existing platforms to become a Silverberry Wellness Ambassador.

For more information and sign up visit Silverberry Wellness Ambassador page.

About Silverberry Genomix
Silverberry Genomix, is a pioneer in DNA Wellness and Health Services. We use Machine Learning (AI) and genetic assessments to help people optimize their fitness plans and daily wellness decisions. By analyzing thousands of genetic variations, Silverberry provides more than 100 DNA Health and Wellness Reports that include: an assessment, recommendations, and additional resources to learn about their genetic traits. Silverberry also offers genetic testing to those who haven’t yet had a genetic test. The DNA Test Kit can be ordered directly from the Silverberry website and is also available for purchase on Amazon. Users who have taken their DNA test with other services can upload their file and receive 10 Free DNA Test Health Reports. For more information visit silverberrygenomix.com

Silverberry Genomix Joins Blockchain

Silverberry Genomix Joins Blockchain

As the first step in the use of blockchain technology, Silverberry announces the acceptance of cryptocurrencies in its store for DNA Testing Kit and Health Reports.

San Francisco, August 16, 2018 - Silverberry Genomix, a pioneer in the use of DNA assessment for health and wellness, announces its first use of blockchain technology.

Due to the rapid development of the genomics market and the use of DNA assessment by a wide range of consumers, Silverberry announced its use of blockchain for the next generation of the Silverberry platform.

“As our services in the DNA market continues to grow, we are focused on developing innovative approaches to advance the technology underlying the service” said Shayan Mashatian, CEO of Silverberry Genomix”. At almost every turn, we find alignment and very useful applications of blockchain technology, from hosting the DNA files on a decentralized network to offer greater control, ownership, and privacy to users, to the use of smart contracts in engaging with our users”, he continued.

As the first step on its road-map to adopt blockchain, Silverberry has added acceptance of popular cryptocurrencies to its online store, including Bitcoin, Ethereum, Bitcoin Cash, and Litecoin.

“Understanding exchanges and cryptocurrencies is the first step in our ability to develop tools to test various blockchain-based usecases. These technologies lay the foundation for full implementation and adoption of blockchain end-to-end. The next phase will include hosting the DNA data on blockchain, implementing smart contracts to engage with the platform, and pilots to scale the technology, including the development of customized algorithms to process and analyze large scale DNA files to produce recommendations based on DNA assessment." announcement concluded.

About Silverberry Genomix

Silverberry Genomix, a pioneer in DNA Wellness and Health Services, uses machine learning (AI) and genetic assessments to help people optimize their fitness plans and daily wellness decisions. By analyzing thousands of genetic variations, Silverberry provides more than 100 DNA Health and Wellness Reports that include an assessment, recommendations, and additional resources to learn about their genetic traits. Silverberry also offers genetic testing to those who haven’t yet had a genetic test. The DNA Test Kit can be ordered directly from the Silverberry website and is also available for purchase on Amazon. Users who have taken their DNA test with other services can upload their file and receive 10 Free DNA Test Health Reports. For more information visit silverberrygenomix.com

 

 

Lactose Intolerance

 

 

Whipped cream, milk, and ice cream: delicious dairy products that up to 65% of the world’s population cannot easily digest. Is your body sensitive to lactose? Learn about the science and genetics behind lactose intolerance and check your genes for this common trait!

A (brief) summary of lactose intolerance

The sugar found in dairy products like milk is called lactose. In order for it to be used as an energy source, it must be broken down into two simple sugars: glucose and galactose. The enzyme that accomplishes this is called lactase. Without the production of lactase in the small intestines, an individual cannot digest lactose and it passes undigested to the large intestines (or colon). Here an individual's bacterial colonies, or gut microbiota, make use of the energy source, but their metabolism of lactose produces gas and other byproducts. The diminished ability to produce lactase and the symptoms of bloating, abdominal cramps, nausea, and diarrhea are referred to as lactose intolerance.

The influence of genes

DNA contains regions that code for enzymes, as well as regions that regulate genes. The lactase enzyme is produced from the LCT gene and has at least one regulator — MCM6. The MCM6 gene that is upstream from, or ahead of, the LCT gene plays a role in regulating the gene. Several genetic variants (or SNPs) in the MCM6 gene have been linked to lactose intolerance.

Check your genetic variants for the “Lactose Intolerance

 

Global genetic varaiations

Interestingly, the SNPs related to lactose intolerance vary widely by ethnicity.

 

In people of European descent, two genetic variants in the MCM6 gene that have been linked to lactose intolerance. [R1]

In people of African descent, research has identified three different SNPs in the MCM6 gene. [R1R2]

In people of Asian descent, studies have identified three additional SNPs in the MCM6 gene. [R1R3]

 

These variations suggest that the mutations developed separately, but for similar reasons — a process called convergent evolution. In other words, the ability to digest milk was incredibly valuable for populations that relied on domesticated animals for food. In times of famine and reduced food availability, those in pastoralist communities who could digest milk were more likely to survive and produce offspring. These strong evolutionary pressures existed primarily in the pastoralist populations in Africa and Europe.

For more, watch this video: “Got Lactase? The Co-Evolution of Genes and Culture”

 

Two types of lactose intolerance - Genetic vs acquired

While pastoralist populations developed the ability to digest lactose throughout the lifespan, all infants have the ability to digest the lactose in human breastmilk.

Primary lactose intolerance is the most common type, and is determined by genes. Normally, an infant’s body produces a substantial amount of lactase to break down all the milk being consumed. As other food begins replacing milk in a child’s diet, the production of lactase decreases. This sharp decrease results in too little lactase for the amount of dairy consumed by a typical adult.

Secondary lactose intolerance on the other hand occurs when the body decreases lactase production following an injury, illness, or surgery related to the small intestine.

Fight Photoaging with Vitamins E & K

The sun is out! Protect your skin from photoaging with the right vitamins and minerals.

Up to 90% of the visible signs of aging — and most types of skin cancer — are caused by the sun’s UV rays. Long-term sun exposure can cause premature aging of the skin, including wrinkles, pigmentation, and sunspots. This is known as photoaging, and the rate at which it happens is influenced by our genes.

How does photoaging happen?

Photoaging is the premature aging of the skin due to repeated exposure to UV radiation. UV radiation causes DNA damage and oxidative stress, a situation in which the production of harmful free radicals overwhelms the body’s ability to neutralize them using antioxidants. In order for the body to protect itself from oxidative stress, the skin produces several enzymes built with antioxidants including vitamin E, vitamin K, vitamin C, vitamin A, iron, and selenium.

While modest UV exposure can prompt the body to increase epidermal thickness, which helps to protect from further UV damage, prolonged exposure overwhelms the skin’s antioxidant defense system. This damage of overexposure, referred to as photoaging, manifests as facial pigmented spots and wrinkles. It is the result of both diminished collagen production (needed to increase epidermal thickness) and diminished antioxidant activity.

Check your Skin Care Reports for the Photoaging, Facial Pigmented Spots, and Skin Antioxidant Deficiency traits.

 

The Importance of Antioxidants

Our bodies produce a number of antioxidative and detoxifying enzymes, such as superoxide dismutases (SODs), to fight free radicals and prevent damage to our skin. However, in order to work properly, SODs require certain minerals, such as copper and zinc, to act as cofactors. To achieve maximum protective capacity, it is important to ensure adequate daily intake of these minerals. This daily need may be higher if you have certain genetic variants that are associated with copper or zinc deficiency.

Check your Nutrition Reports for these traits!

Additionally, genetic variations in the NRF2, SOD2, and CAT genes have been associated with reduced antioxidant activity in cells throughout the body and an increased risk of damage to lipids and proteins in the skin. It is even more harmful for individuals with these genetic variants to have reduced dietary intake of antioxidants — i.e. to not get the recommended FIVE daily servings of vegetables and fruits.

Do you need to keep a close eye on your vegetable intake? Check your risk of “Skin Antioxidant Deficiency.”

 

Vitamins E and K Fight Photoaging

Vitamin E is a fat-soluble antioxidant which absorbs UV rays from the sun to protect your skin, thus preventing wrinkles, dark spots, and certain types of skin cancer. It is an essential ingredient in the sebum, the oil secreted by the skin for protection and hydration. Vitamin E’s anti-inflammatory and hydrating properties keep the skin looking youthful. In order to maximize its benefits as an antioxidant, make sure to get enough vitamin C and B3 as well because their presence enhances vitamin E’s activity.

Vitamin E: How Much and From Where? Check this handy guide.

While vitamin E prevents photoaging by acting as an antioxidant, vitamin K works to treat other skin troubles to keep the skin healthy and youthful, minimizing the effects of photoaging. Its main functions as a vitamin are blood clotting to heal wounds and strengthening capillaries to heal bruises. Vitamin K additionally helps treat spider veins, stretch marks, and dark spots, while increasing circulation to reduce undereye darkness and puffiness. Vitamin K: How Much and From Where? Check this handy guide.

Fun fact: A recent study found that the MC1R gene, which is responsible for pale skin and red hair, is also linked to increased photoaging.

This gene codes for a protein that plays a role in normal pigmentation. It is found on the surface of melanocytes, which are cells responsible for the production of melanin — the pigment giving skin, hair, and eyes their colour. There are 2 types of melanin produced: eumelanin and pheomelanin. People with more eumelanin tend to have brown or black hair and skin that tans easily. On the other hand, people with more pheomelanin production tend to have blonde or red hair, freckles, and less protection from UV rays and photoaging. One gene responsible for the synthesis of pheomelanin is the ASIP gene. Having variants of this gene could lead to an increased risk of facial pigmented spots with sun exposure, as it would lead to the clumping of melanin to form areas of hyperpigmentation. [NIH]
If you are worried about photoaging, protect yourself! By having a diet with sufficient vitamins, minerals, and antioxidants for your genetic makeup, you can reduce your the risk of photoaging and have plenty of fun outside this summer. ??

Don’t forget your daily dose of vitamin C!

What are the real benefits of vitamin C?

Vitamin C, also known as ascorbic acid, is a potent antioxidant which is essential to the normal functioning of our immune system [1]. It boosts our immune system and helps us fight a cold by encouraging the production of white blood cells, lymphocytes, and phagocytes, which are key players in fighting infection. It also helps with red blood cell production and the growth and repair of all connective tissue. Higher blood levels of vitamin C have been linked to a wide range of benefits such as a lower risk of cardiovascular disease and cancer, as well as increased vitality and longevity. It contributes to longevity by boosting collagen synthesis and reducing the risk of joint injury with age. Collagen synthesis is important for both strengthening tendons and ligaments, as well as reducing wrinkles in our skin.

[Check your Longevity or Skin Care Reports for traits such as Collagen Breakdown and Skin Antioxidant Deficiency to see if you might have a higher need for vitamin C!]

How do my genes influence how much vitamin C I need?

While vitamin C’s benefits are available to everyone, some people need to consume more vitamin C-rich foods in order to achieve the health-protecting levels in the blood. Vitamin C intake requirements vary from person to person and are partially related to genetics. SLC23A1 and SLC23A2 are two vitamin C transporter genes responsible for absorption of the vitamin in the gut. Certain variants of these genes have actually been shown to decrease the efficiency with which the body can absorb vitamin C. Thus individuals with these inhibitory genetic variants would benefit from an increased nutritional intake of vitamin C. 

Due to its water-soluble nature, vitamin C cannot be stored in the body and excess amounts are usually secreted within 24 hours of intake. This makes it necessary to include foods rich in vitamin C in our daily diet.

6 fruits high in vitamin C: Kiwi, oranges, guava, pineapples, strawberries, grapefruit

6 vegetables high in vitamin C: Kale, broccoli, parsley, brussel sprouts, red and green peppers, peas

Daily Recommended Intake of Vitamin C [2, 3]

Woman over 18 years of age: 75 mg/d

Men over 18 years of age: 90 mg/d

 

 

Vitamin C and Iron

Another one of vitamin C’s benefits is its ability to aid in the absorption of iron. This is especially important for women, since they have a higher daily requirement for this mineral [8.1 compared to the 6 mg/day needed by men]. Iron is a component of hemoglobin, a multimeric protein in our red blood cells that grabs oxygen and carries it through our body. Iron is what actually binds the oxygen molecules, making it hugely important in our body. A lack of enough hemoglobin, and thus iron, results in a condition known as anemia, with symptoms such as fatigue and shortness of breath. Vitamin C aids in iron absorption by limiting the formation of an insoluble form of dietary iron and transforming it into an absorbable form. [4]

If your Vitamin Reports show a predisposition for Iron Deficiency, consider increasing your intake of vitamin C alongside iron intake!

 

Keep in mind:

  • Natural sources of vitamins are almost always better than supplements, as they are easier to absorb. [Hence the need for supplements to contain 1000% of Daily Value.]
  • Fruits and vegetables differ greatly in the density of vitamins and minerals. For example, parsley may contain 133% DV of vitamin C per cup, but no one is trying to eat that much parsley in a single sitting. When planning to meet your daily requirements, always consider serving size.
  • The amount of vitamin C that is available for absorption can also depend on whether the foods are raw or cooked, so variety is key!

 

The Mediterranean Diet – Is this the one?!

Eating healthy doesn’t have to mean being restrictive, but rather being mindful of which foods work best for your body. To assess whether a certain dietary plan is best for you, it’s important to look at genetic predispositions you may have for a variety of influential traits, from nutrition to personality!

The Mediterranean diet consists mainly of plant-based foods such as fruits and vegetables, nuts and whole grains. It incorporates healthy fats, such as the monounsaturated fats [MUFAs] found in olive oil or avocados, and emphasizes fish while limiting red meat.

How could my genes affect the outcome of this diet?

Genetic variations in the ADIPOQ gene have been found to be associated with an increased advantage of following the Mediterranean diet, as a way to facilitate fat loss and improve metabolic health. Other genes contributing to the effectiveness of this diet include PPARG and LPL. Do you have any of these genes? All three of these genes are related to fat storage and are produced by your fat [adipose] cells. Imagine your fat storage apparatus as the organizational system in an airport. Molecules of fat would be the suitcases to be stored within the airplanes, or cells. PPARG is responsible for directing which line and to which gate the suitcases need to go through in order to reach the right plane. When suitcases are being checked in, adiponectin would in charge of determining how much space is available to accommodate them. Finally, the enzyme LPL is the labourer who does the hard work, loading each suitcase onto the planes, like molecules of fat entering the cells.

Variants of the mentioned genes could result in an LPL that doesn’t work as hard, for example, or PPARG that has trouble signalling efficiently. Due to these variations in how each person’s body deals with fat, the Mediterranean diet, rich in healthy fats, can be more beneficial for some than others.

Your Basic Wellness Package includes a report on the effectiveness of the Mediterranean diet for your health and wellness. However, having a genetic predisposition for this trait may not necessarily mean it is practical or even maximally effective for you. This is due to the fact that a combination of different traits affect how you lose weight, which nutrients your body needs most, and even how easily you embrace a specific lifestyle change. Delve a little deeper and find out!

What other traits should I look at?

For example, if your Vitamin Reports show a predisposition for Iron Deficiency and Vitamin C Deficiency, you may need to supplement your diet with foods rich in iron and vitamin C, such as oranges, strawberries, spinach, and poultry. Due to these predispositions, relying solely on the Mediterranean Diet — which is not particularly rich in these vitamins — would not be enough to cover all your body’s nutritional needs.

Example 2: If you are elevated for Sweet Tooth and Carb Overconsumption, you may find it more difficult to reduce your sugar intake and moderate your carbohydrate consumption. Thus embracing the Mediterranean diet, with its focus on carbs from vegetable, fruits, and whole grains and minimization of sweets, could be more challenging for you than the average person.. If you know whether you have predispositions for these traits, you can be aware of what makes a certain diet challenging for you to follow, and focus on making the necessary  adjustments.

Example 3: If someone has a predisposition for Satiety Impairment and Fat Taste Perception, the increased protein and healthy fats of the Mediterranean diet would help contribute to satiety and make the diet easier to follow.

 

Learn more and read a sample report here 

It’s All About Vitamin D!

Several studies have examined the relationship between vitamin D and mood disorders such as depression and seasonal affective disorder [SAD].

(Check your genes for SAD or Seasonality!)

One study found that depression was greater, as assessed by the Hospital and Anxiety Depression Scale (HADS), in people with deficient levels of vitamin D compared to people with normal levels. It was also found that just 1 hour of light therapy a day during winter months significantly decreased symptoms of depression in people with SAD, as compared to the control group. No wonder we tend to feel better when it's sunny! Interestingly, in addition to mood, another study found a link between vitamin D deficiency and worse cognitive performance in older adults.

Vitamin D production is initiated by sun exposure and is impacted by age, location (latitude), time of year, as well as the amount of melanin our bodies have, corresponding to skin pigmentation or colour.
If your Vitamin D Deficiency trait is at all elevated, check your Skin Care Report for traits such as Sensitivity to Sun, Facial Pigmented Spots, Poor Tanning Ability, etc. You may have genetic predispositions that increase the risk of sensitivities due to UV rays of the sun, making it a wiser choice to incorporate foods rich in vitamin D into your diet and to avoid prolonged exposure to the sun!

If you have a poor tanning ability for example, your skin may have lower levels of melanin, a natural pigment produced by the body. Melanin reacts with UV rays to produce a darker skin tone as a way of adaptation (tanning), and so in some ways it provides the skin with protection and tolerance to the sun. Having less melanin (and so lighter skin) means the skin can be more prone to sensitivity, sun burn, and skin disease.

Variants of genes such as PDE3B, CYP2R1, and NADSYN1 contribute to the Vitamin D Deficiency trait. Check your Vitamin Reports Package to see if you have any of these genes!

Always remember, having a genetic predisposition doesn’t necessarily mean the genes are active and the trait is expressed, so consult a healthcare professional before making major changes to your lifestyle. They can order blood tests to verify nutrient deficiencies and determine if supplementation is necessary.

Alexa is Genius Now!

San Francisco, September 15th, 2017 – Silverberry Genomix, a DNA Lifestyle company announced launch of its Alexa Skill, Gene of The Day.

Gene of the Day provides facts about genes and how they influence our unique body in different ways.

Silverberry’s Alexa app is the first one in a series of services offered to market for personalized wellness information based on genomics studies and machine learning techniques. In next version, each user will be able to hear personalized report based on their Silverberry Genomics assessment. The assessments are offered in the areas of Nutrition, Skincare, Sports and Exercise, Allergy and Personality Development.

Alexa users can add the skill to their Daily Flash Briefing and learn about one trait every day.

Alognwith release of its Alexa app, company announced a special promotion for the user who don’t have Amazon Echo device. For a limited time, they receive an Amazon Echo Dot for free  when they order a wellness reports package.  more information can be found at http://35.239.52.54/alexa

for more information about Silverberry Genomix and its services visit http://35.239.52.54