Choline: The Skinny

Did you know?

A whopping 90% of Americans are not meeting their daily choline needs!

What's worse, the estimated daily requirement could be an underestimate because many common genetic variants increase choline needs.1

Why do I care about choline?

3 BIG reasons:

It is used for [1] building cells, [2] sending nerve signals, [3] and turning genes on and off.

Life without choline:

Organ failure and mental degeneration.

Life with choline:

Faster thinking, improved coordination and memory.

Choline is used to make two of the four main components in cell membranes — phosphatidylcholine and sphingomyelin. Without choline and without cells, you would suffer the tragic fate of Senator Kelly in X-Men — and end up as a jellyfish-like puddle on the floor. Plus, sphingomyelin is used in the insulation around your nerve cells [AKA the myelin sheath] and without it your nerve signals don't move quickly and efficiently.

Don't end up like Senator Kelly, get your daily dose of choline!

Choline is quite the workaholic — it is also involved in turning genes on and off. Choline is the main contributor of methyl groups for methylation reactions.2  Methylation is an important regulatory mechanism/process, in which methyl groups are used as biological tags — or sticky notes — and attached to various cellular components. The methylation of DNA, for example, is used to turn specific genes on and off, in a process called epigenetic modification.

Honorable mentions:

The production and recycling of methyl groups also relies upon vitamins B9 (folate), B6, & B12. In fact, a reduction in any of these nutrients can have an effect on the others. In other words, if you skimp on those, choline will pick up some of the slack... at least for a little while.
Who has a higher risk of deficiency?

Bodybuilders, pregnant women, vegans, vegetarians, and people with certain genes.

  • Bodybuilders and athletes who have really high cellular turnover, i.e. are building a lot of new cells, have higher requirements for choline. As do pregnant women — for the same reason!
  • Vegetarians and vegans who forego choline-rich animal foods — like eggs, salmon, and dairy — are at a greater risk of deficiency.
  • Certain genetic variants can increase choline needs.
How does genetics play a role?

Remember those B vitamins that received honorable mentions?

While members of this Brat Pack often act together to provide methyl groups, they also take on solo roles. Just like choline is called upon to build cells, folate is used to build DNA. A genetic variant in the MTHFD1 gene shifts folate into its other roles, leaving choline to pick up the slack. That can increase your choline needs.3

 

Remember choline's role in creating one of the major components of cell membranes — phosphatidylcholine?

There are two ways to make it. The first and primary method is much more efficient than the second, but just like the federal government, the human body loves redundancies. The second production method is more resource intensive, but useful in a pinch. [For any science nerds out there, this is a battle between the CDP and the PEMT pathways.4] Different genetic variants push production down one pathway or the other. If your genetics favor the less efficient pathway, your body is going to need more raw materials to get the job done. Time to feed the machine!

Where do I get it?

Choline-rich foods include eggs, salmon, and dairy. Vegetarian sources include soybeans, peanuts, broccoli, and cauliflower. Unfortunately, these vegetarian sources include only a half or one-third as much choline as the animal sources, so be sure to load up on that broccoli!

Check your Silverberry Product Collection if you need some extra help getting the recommended dose of choline.

Product Spotlight

The Silverberry Product Collection currently includes 8 supplements that contain choline. They are:

  • Adult B-Centered™
  • Baby and Me 2
  • Multi for Women, Multi For Women 40+, and Multi for Women 55+
  • Multi for Men, Multi for Men 40+, and Multi for Men 55+

Adult B-Centered™ by MegaFood

This week we shine the spotlight on Adult B-Centered™.

This supplement is a good option for covering your bases with the methyl donors. For example, if your choline needs are high because of altered folate metabolism — you kill two birds with one stone.

The supplement includes vitamins B1, B2, B3, B5, B6, B7, B9 (folate), B12, choline, and zinc. Additionally, the B9 (folate) and B12 come in their methylated forms. These are the active forms more easily utilized by the body.

View your Product Collection to find out if this product is suggested for you.

Silverberry Newsletter, August 10th, 2018

To our fellow genetics enthusiasts,

This week newsletter is about your privacy and we review some “cheesy genes”! Plus top news in the genomics world.

Gene Spotlight

All about Lactose Intolerance ?

Whipped cream, milk, and ice cream: delicious dairy products that up to 65% of the world’s population cannot easily digest.

Is your body sensitive to lactose? Learn about the science and genetics behind lactose intolerance and check your genes for this common trait!

Celebrate Summer with 10% Discount

Join us to celebrate the summer with 10% discount on all Silverberry packages. Protect your skin from sun by choosing the best DNA-Based advise, optimize your diet and focus on exercise that has the most benefit for you!

Use SUMMER as discount code on checkout.

Offer ends on August August 19, 2018, 11:59 pm. Discount doesn’t apply to previous orders and can not be combined with other promotions. Applicable taxes and shipment excluded from discount.

Couple & Family Edition

We understand how important it is to know about the wellness and health of loved ones, so we are pleased to introduce the new Couple and Family Editions of our packages! These bundled products are designed to make the DNA reports accessible to all family members by offering group discounts.

These new editions are available for our most popular package — DNA Kit & Comprehensive Reports — which provides a complete DNA  health profile with recommendations along with ancestry reports.

The Couple Edition

13% Discount: 2 DNA Kits with the Comprehensive Reports for $499

The Family Edition

20% Discount: 4 DNA Kits with the Comprehensive Reports for $92

The Comprehensive Wellness Reports include ~140 genetic trait reports.

Your DNA Data Privacy

Last week we released a new page that outlines the principles we follow to protect your DNA file and personal information.

You can find all the details you need to know in a simple format, from what personal data we collect, data sharing policies and more.

click on below button if you missed it.

 

 

 

Genes Making Waves

Could blockchain technologies help US healthcare companies better manage patient information?

US health care companies are beginning to explore blockchain systems, most commonly known in connection with cryptocurrencies like Bitcoin. Such technologies could securely store updated patient data across different health care providers and be easily shared with other providers when needed. [The Conversation]

Genome editing to pick characteristics of future children deemed “morally permissible” by ethics group.

Human genome editing is “morally permissible” in certain cases according to the Nuffield Council on Bioethics. This has sparked a debate around “designer babies”, preventing the lives of people with genetic conditions, and the impact of such technology on the future of our society.
[The Independent]

23andMe’s pharma deal has customers angry.

23andMe has announced a deal with one of the world’s biggest pharmaceutical companies, GlaxoSmithKline, giving them exclusive rights to the behavioural, health, and genetic information of 80% of their customers.  [Wired]

Silverberry Newsletter, July 13, 2018

This week’s newsletter is all about preventing photoaging and the new Fitness Club Partnership Program.

Ours genes have a lot to do with how fast our skin shows signs of aging. Learn about the contributing genes, vitamins, and minerals and prevent photoaging.

Don't forget: The Silverberry Fitness Club Partnership Program is bringing DNA assessment to gyms and fitness centres.

Here's the latest on Silverberry, the world of wellness, and genetic advancements.

Gene Spotlight

The sun is out! Protect your skin from photoaging ☀︎ 

Up to 90% of the visible signs of aging and most types of skin cancer are caused by UV rays of the sun. Long-term sun exposure can cause premature aging of the skin, which encompasses various skin troubles such as wrinkles, pigmentation, and sun spots.

This is known as photoaging and the rate at which it happens is influenced by our genes.

Silverberry Fitness Club Partnership Program

The Fitness Club Partnership Program is pleased to bring DNA assessment to gyms and fitness centres that would like to offer the latest advancements in science and technology to their members. Along with the Certification Course, wellness coaches and personal trainers can create personalized fitness plans with genetic assessment to optimize results.

 

Silverberry Genomix Hackathon

Illumina Accelerator joins hackathon!

With great enthusiasm, Silverberry Genomix welcomes Illumina Accelerator to the panel of judges at the Silverberry DNA Hackathon!

The Illumina Clinical Services Laboratory is a proven and trusted partner in the new era of using genomic information to make critical health care decisions, and offers a comprehensive portfolio of clinical whole-genome sequencing tests intended to help both diagnose and assess risk for certain genetic diseases.

 

Don't miss this special event!

TheSilverberry Hackathon will bring together wellness enthusiasts like you, data scientists, developers, and designers, over an intense 24-hour period of creative explosion. 
Bring your enthusiasm and ideas! Learn from the experts while helping build the next generation of innovative DNA-powered health solutions! 
July 20-21, 2018 @ Galvanize   |   44 Tehama St, San Francisco CA   |   Read More

 

Join the Discussion

Facebook Group

Join us along with other Silverberry members to share your ideas, provide us with feedback, or ask your questions! 

Join Group

 

Silverberry Club Forum

Join fellow fitness enthusiasts and healthcare providers at the discussion forum.

Ask your questions here!

 

Genes Making Waves

Gene editing prevents deafness in mice.

A Harvard and MIT study has been able to prevent progressive hearing loss in mice with a genetic mutation that bound them for hearing loss, with a single injection. Could this lead the way for prevention of hereditary hearing loss in humans?
[The Guardian]

Personalized medicine: Why one size doesn’t fit all when it comes to cancer treatment.

Genetic testing at the University of Utah’s Huntsman Cancer Institute was able to identify a specific mutation in a cancerous tumor, the right type for a targeted drug. This saved the life of a 71 year old with stage IIIA lung cancer, opening the door to further research and expansion of personalized medicine.
[U.S. News]

Can the genes behind tanning help us understand the onset of skin cancer?

King’s College of London has led a large study with data from over 200,000 people that discovered genes influencing whether our skin sun tans or burns. Many of the discovered genes were found to be involved in skin cancer, linking scientists’ understanding of the genes behind tanning with the onset of skin cancer. 
[Independent]

Silverberry Newsletter, June 29, 2018

This week’s newsletter is all about Exercise Aversion and the new Fitness Club Partnership Program.

Silverberry is bringing DNA Assessment to gyms and fitness centres! Learn all about this new partnership program.

Don't forget: If you suffer from insomnia, you might consider joining us for a 24-hour hackathon in the Galvanize speakeasy.

Here's the latest on Silverberry, the world of wellness, and genetic advancements.

Gene Spotlight

Where does our motivation for exercise come from? 

Studies have found that up to 50% of our like or dislike for exercise can be due to our genes...

Learn more by listening to this short Gene of the Day featuring Exercise Aversion.

Silverberry Fitness Club Partnership Program

The Fitness Club Partnership Program is pleased to bring DNA assessment to gyms and fitness centres that would like to offer the latest advancements in science and technology to their members. Along with the Certification Course, wellness coaches and personal trainers can create personalized fitness plans with genetic assessment to optimize results.

 

Silverberry Genomix Hackathon

Don't miss this special event!

The Silverberry Hackathon will bring together wellness enthusiasts like you, data scientists, developers, and designers, over an intense 24-hour period of creative explosion. 
Bring your enthusiasm and ideas! Learn from the experts while helping build the next generation of innovative DNA-powered health solutions! 
July 20-21, 2018 @ Galvanize   |   44 Tehama St, San Francisco CA   |   Read More

 

Join us at the IDEA Fit Conference

Silverberry will be exhibiting at the IDEA Fit Conference in San Diego, from June 28th to June 30th. You can join the expo for free and meet the Silverberry team (Booth #747 in the Nutrition area), learning about new technology and training tools among fellow personal trainers, health coaches, and innovators.

 

Join the Discussion

Facebook Group

Join us along with other Silverberry members to share your ideas, provide us with feedback, or ask your questions! 

Join Group

 

Silverberry Club Forum

Join fellow fitness enthusiasts and healthcare providers at the discussion forum.

Ask your questions here!

 

Genes Making Waves

Gene editing produces pigs resistant to the world’s most costly animal disease.

Scientists at the University of Edinburgh have been able to successfully produce pigs that do not become infected by the deadly Porcine Reproductive and Respiratory Syndrome (PRRS). They’ve done so by editing the genetic codes of these pigs, which showed no signs of any impact on their wellbeing. [Science Daily

 

‘Gene map’ of depression opens the door for more effective treatments

A team of over 200 researchers have discovered 30 new gene variants that increase the risk of depression. With this, they hope to understand why certain people suffer from the disease while other do not, even with similar life experiences. [The Guardian

 

Can our genes record our time of death?

Recent research has found that some of our genes continue to be active and perform transcription even after we die, displaying activity patterns that can roughly estimate when the time of death was. Similarly, our molecular processes continue to work after death until the necessary enzymes and chemicals run out. But at what point does that happen? [Science News

Silverberry Newsletter, June 22, 2018

This week’s newsletter is all about the vitamin C and joining the DNA-powered healthcare revolution.
 
Vitamin C is a pretty phenomenal vitamin, a multitasker, and a potent antioxidant. Find out what other traits it is connected to with this week's "Gene Spotlight."

Never been in a hackathon or don't know anything DNA? We've got the perfect opportunity for you! Come join the Silverberry DNA 24-hour hackathon in the Galvanize speakeasy.

Here's the latest on Silverberry, the world of wellness, and genetic advancements.

 

Gene Spotlight

Don't forget your daily dose of vitamin C!

Did you know that humans are one of the few mammals who have lost the ability to synthesize their own vitamin C? You’ve probably heard that vitamin C is important when it comes to fighting off a cold, but that’s not all it’s good at!

Our genes can actually influence how much of it we need to eat in order to get all the health benefits vitamin C offers.

Have Alexa? Add Gene of the Day to your daily briefing or listen to it online.

 

Silverberry Genomix Hackathon

Don't miss this special event!

The Silverberry Hackathon will bring together wellness enthusiasts like you, data scientists, developers, and designers, over an intense 24-hour period of creative explosion. 
Bring your enthusiasm and ideas! Learn from the experts while helping build the next generation of innovative DNA-powered health solutions! 
July 20-21, 2018 @ Galvanize   |   44 Tehama St, San Francisco CA   |   Read More

 

Join us at the IDEA Fit Conference

Silverberry will be exhibiting at the IDEA Fit Conference in San Diego, from June 28th to June 30th. You can join the expo for free and meet the Silverberry team (Booth #747 in the Nutrition area), learning about new technology and training tools among fellow personal trainers, health coaches, and innovators.

 

Pondering Your DNA Reports?

Facebook Group

Join us along with other Silverberry members to share your ideas, provide us with feedback, or ask your questions! 

Join Group

Silverberry Club Forum

Join fellow fitness enthusiasts and healthcare providers at the discussion forum.

Ask your questions here!

 

Genes Making Waves

Could drinking coffee save Type-2 diabetics from insulin injections?

Researchers in Switzerland are hoping to change the lives of diabetics by developing an implant that releases insulin when triggered by caffeine from coffee, tea, or energy drinks in the bloodstream. “According to [them], the future of diabetes will not be a shot in the arm after a meal, but a shot of espresso instead.” [The Guardian]

 

Are human herpesviruses involved in Alzheimer’s disease?

A new study funded by the NIH has found compelling evidence that human herpesviruses HHV-6A and HHV-7 could be involved in “regulatory genetic networks” that may lead to Alzheimer’s disease. [Medical News Today]

 

New Vox episode delves into why diets fail.

Vox has a new episode of its show, “Explained” on Netflix. In this one they look at the influence of marketing, food environments, and genes to explain why so many diets fail. [Vox]

Silverberry Newsletter, June 8th, 2018

To our fellow genetics and fitness enthusiasts,

We are pleased to announce the start of our weekly newsletter where we share important reminders, interesting articles related to health and genomics, and our "Genetic Trait Spotlight" to help you get the most out of your Wellness Reports.

We've got a lot going on in the upcoming months and the developments in genetics aren't slowing down either! Here's the latest on Silverberry, the world of wellness, and genetic advancements. 

Gene Spotlight

It's All About Vitamin D!

Did you know that vitamin D is associated with several aspects of our health? Multiple studies suggest a correlation between sun sensitivity, memory performance, depression, and how the body produces and uses vitamin D.

Read more

Join us at the IDEA Fit Convention

Silverberry will be exhibiting at the IDEA Fit Convention in San Diego from June 28th to June 30th! You can visit the expo for free, meet the Silverberry team, and join fellow personal trainers, health coaches, and innovators to learn about new technology and training tools. 

Get your FREE ticket to Expo

Father's Day Special

Order now and save 20%

Silverberry Certification Course

 

 

 

The Silverberry Certification Course is now on UDemy!

Learn how to create personalized exercise and nutrition plans using genetic assessment.

Take me to the UDemy course

Genes Making Waves

Are we one step closer to directly targeting cancer cells?

UCLA scientists are now able to see the inner workings of telomerase, an important enzyme closely tied to cancer and aging, with near atomic resolution. Could this lead the way to the development of targeted drugs? [Science Daily]

Netflix series "Explained" releases an episode all about DNA.

A 20-minute episode entitled "Designer DNA" covers a bit of genetics, with a heavy focus on the new gene editing technology shaking up the industry [along with ethicists].  One of the researchers who discovered CRISPR, Jennifer Doudna, explains the tool she stumbled upon - a potential force for good, and evil. Sadly, the full episode is only for Netflix subscribers, but others can check out a clip at Vox. [Vox]

At-home DIY gene editing has people nervous.

Several companies are now offering gene therapies you can assemble at home and self-administer. [Popular Mechanics]
Former Nasa biochemist Josiah Zayner injects himself with a DIY gene therapy on live-stream internet to dramatically increase muscle mass. [The Guardian]